What is a preservative-free nasal spray?

A preservative-free nasal spray is a nasal spray that is manufactured aseptically to prevent microbial growth rather than having a preservative included in its formulation. To achieve this, bulk drug product is filtered through a 0.22um filter prior to being filled into a nasal spray vial under aseptic processing conditions. After filling and while still in a grade A environment, a preservative-free nasal spray pump is applied. These pumps are specially designed to include a filter that prevents microbial contamination of the formulation from outside air after actuation.

Renaissance is one of only a few contract manufacturers (CMO) worldwide with the capability of manufacturing preservative-free nasal spray products. We can fill these products at both clinical and commercial scales. Contact us to learn more about our preservative-free nasal spray manufacturing capabilities.